Dr. Pill is a falling block tile-matching video game, tossing two-colored medical capsules into a medicine bottle representing the playing field. The player manipulates each capsule as it vertically falls 1 unit of space at a time, able to move it left or right and rotate it 90 degrees in either clockwise or counter-clockwise. When four or more capsule halves or viruses of matching color are aligned in vertical or horizontal configurations, they are removed from play. The main objective is to complete levels, which is accomplished by eliminating all viruses from the playing field. A game over occurs if capsules fill up the playing field in a way that obstructs the bottle's narrow neck.