A drug interaction reference tool focused on the human cytochrome P450 system.
Version
1.0.0 ( 100013 )
Update
Mar 27, 2023
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The Flockhart Table (TM) is a drug interaction reference tool focused on the human cytochrome P450 system.
This drug interaction app is designed as a teaching and reference tool for health care providers (e.g., physicians, pharmacists, nurses) and researchers interested in drug interactions mediated by the cytochrome P450 system.
Drug substrates are classified by cytochrome P450 isoform(s) based on published evidence that the specific isoform(s) contributes to the metabolism of the drug. It does not necessarily follow that the isoform is the principal metabolic pathway in vivo, or that alterations in the rate of the metabolic reaction catalyzed by that isoform will have large effects on the pharmacokinetics of the drug.
The Flockhart Table (TM) only catalogs drug-drug interactions that are mediated by CYPs. Drug-drug interactions caused via other enzymes (e.g., UGTs) are not included in this table. In addition, some of the drugs listed here could be substrates of uptake and efflux drug transporters. However, drug-drug interactions caused by inhibition or induction of drug transporters are not included in this table.
This app is dedicated to the memory of a pioneer in clinical pharmacology and pharmacogenetics and the creator of this site, Dr. David A. Flockhart, MD, Ph.D.
This drug interaction app is designed as a teaching and reference tool for health care providers (e.g., physicians, pharmacists, nurses) and researchers interested in drug interactions mediated by the cytochrome P450 system.
Drug substrates are classified by cytochrome P450 isoform(s) based on published evidence that the specific isoform(s) contributes to the metabolism of the drug. It does not necessarily follow that the isoform is the principal metabolic pathway in vivo, or that alterations in the rate of the metabolic reaction catalyzed by that isoform will have large effects on the pharmacokinetics of the drug.
The Flockhart Table (TM) only catalogs drug-drug interactions that are mediated by CYPs. Drug-drug interactions caused via other enzymes (e.g., UGTs) are not included in this table. In addition, some of the drugs listed here could be substrates of uptake and efflux drug transporters. However, drug-drug interactions caused by inhibition or induction of drug transporters are not included in this table.
This app is dedicated to the memory of a pioneer in clinical pharmacology and pharmacogenetics and the creator of this site, Dr. David A. Flockhart, MD, Ph.D.
